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Headache-Adviser Newsletter, Issue #012- New Effective Migraine Medication
November 28, 2008

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Greetings and I hope you had a wonderful headache free Thanksgiving. Mine was full of turkey and stuffing and a great family visit.

On to the news..published in Lancet (a medical journal) this week was the results of research done by Merke Research regarding a new drug call Talcagepant. Don't ask me how to pronounce this and who thinks up these names anyway?

This drug is part of a new class of migraine drugs called calcitonin G receptor antagonists (or blockers).

"Calcitonin gene-related peptide (CGRP) is a neuropeptide thought to have a key role in the pathophysiology of migraine, they write. CGRP receptors are found throughout the trigeminal pathways involved in migraine headache pain, and antagonism of these receptors has become an important target for new migraine treatments, they write. Telcagepant is an orally bioavailable antagonist of the CGRP receptor"

This drug is designed like the triptans to be taken at the onset of a migraine. It was found to be as effective as Zomig in treating a migraine and has somewhat less side effects. There seems to be less chest tightness, throat tightness and dizziness.

This is probably due to the fact that some of the triptans can effect the same receptors in the brain responsible for anxiety..and those symptoms above are also signs of an anxiety attack.

The first trials are now over and more research on this drug with larger populations will most probably be conducted. One of the doctors noted that this could be "a new era" in the treatment of migraine..let's hope he is right!

You can read more about this at Medscape News.

Enjoy the holidays and try to keep the stress levels down. For some tips on how to do this visit Holiday Headache Tips from

Here's To Headache Free Days

Take care..

Mary Kay Betz, MS RPA-C
Physician Assistant

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