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Tylenol Side Effects

Tylenol side effects are generally very minimal. Unlike other over the counter medications, there usually is no upset stomach which makes it a good alternative to Advil or Aleve.


There are a few chronic medical conditions to be concerned with. Tylenol side effects can include problems with people taking other medications or have conditions involving the liver. Acetominophen is metabolized through the liver and can effect other medication levels.

Conditions where you should NOT take Advil or Motrin(ibuprofen):

  • Daily use of alcohol, more than 3 drinks per day
  • Chronic liver disease, such as hepatitis
  • Daily use of carbamazepine
  • Known or suspected allergy to the drug
  • Daily use of Warfarin, Coumadin or any anti-coagulant therapy
  • Daily use of isoniazid
  • Known or suspected allergy to acetominophen

Common Tylenol Side Effects

Rashes. This is usually an indication of drug allergy (1-3% incidence) so the medication must be stopped immediately. If swelling of the lips or throat occurs, take bendryl immediately (if not allergic to that too!) and get to a doctor or emergency services. Swelling in the throat means swelling in the larynx and you run the risk of not being able to breath.

Pregnancy This drug has been used for over 40 years as the drug of choice for pain relief when pregnant. It has been shown to be safe for mother and child, but as always, discuss this first with your doctor. If possible, medications should be avoided during pregnancy.

Kidney effects. All available studie have shown it is not nephrotoxic (toxic to the kidneys).

Cardiovascular effects. No obvious effects on the cardiovascular system.

Nervous system effects. No obvious effects on the nervous system.

Liver effects. See above. This is especially important if you have hepatic fibrosis (mild scarring in the liver) or cirrhosis (permanent nodules of scar tissue). While this can happen from medical conditions, the most common cause is alcoholism. Tylenol and any acetominophen products should be avoided in alcoholics.

As you can see, tylenol side effects are generally mild and it is considered a safe drug..

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